forefoot sprain treatment

Diagnosis begins with a physical examination that may include gentle manipulation of the injured toe to feel for a dislocation or break. This is known as overpronation. To better understand your doctors diagnosis, its helpful to know the basic anatomy of the toes. reusable, and completely removable. Patients with ankle sprain should use cryotherapy for the first three to seven days to reduce pain and improve recovery time. Start with a heel strike and once you get to the forefoot push-off, come up onto the toes. Dislocated toes can usually be treated with closed reduction, but sometimes an open reduction (surgery) is necessary. Learn more about the differences between sprains and strains here, https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=134&contentid=514, https://radiopaedia.org/articles/bone-contusion?lang=us, https://www.aafp.org/afp/2017/0701/p44-s1.html, https://www.niams.nih.gov/health-topics/sprains-and-strains, https://www.aocd.org/page/SubungualHematoma, https://orthoinfo.aaos.org/en/diseases--conditions/toe-and-forefoot-fractures/. For others, especially if the dislocation was in a big toe or is severe, it may take up to eight weeks to resume normal activity. Lisfranc injuries include ligament strains and tears, as well as fractures and dislocations of bone (far right). Mortons neuroma or Mortons syndrome is a compressed nerve in your forefoot, causing pain between the third and fourth toes. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Rest until the pain has gone. A mild, grade 1, midfoot sprain can be managed non-operatively with a short period of immobilization in a hard-soled shoe or a removable boot. the pain is severe and does not go away after several hours, it is difficult to walk or to put weight on the foot, the toenail falls off or the area around it is very swollen, there are signs of infection around the toenail, such as itching, redness, and pus, a broken toenail does not stop bleeding after several minutes, the toe is numb, as this may indicate a nerve injury. Is it stubbed, bruised, broken, or sprained? 2004-2022 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. But in many people, the foot rolls in too much. A midtarsal joint sprain is an injury to the ligaments which hold the tarsal bones in the middle of the foot together. However, these are usually unnecessary except in unusual cases. A less severe type of injury is a sprained big toe, often called turf toe. This is still a serious and painful injury and can have a lot of the symptoms of a dislocation. Although many fractures heal on their own, a doctor may need to surgically repair a severe fracture. If the joint feels unstable, its a sign of possible dislocation. Surgery if the bursitis is particularly bad and does not respond to conservative treatment then surgery is also an option. Stretching exercises, in particular for the calf muscles should be done when recovering from Achilles-related injuries. Midtarsal Joint Sprain. Treatment options and prevention for a foot sprain. Delaying treatment of Lisfranc injury can cause long-term or permanent damage. Closed reduction can be painful, and your doctor may give you a sedative or inject a local anesthetic to help you manage. Things you can do before you can get to a doctor are: These measures apply to people of all ages. The bones of your toe can be dislocated by jamming your toe or by any injury that causes bending or twisting. Some common causes include accidentally kicking the toe into a wall or doorframe, tripping over a toy on the floor, or catching the toe on a gate or other object. People may notice the following injuries after stubbing their toe: A subungual hematoma is a spot of blood under the toenail. A subluxation is a partial dislocation, where the bones are out of position, but not completely separated. Swing the other leg forward and heel strike with the next foot to continue. All rights reserved. The three toe joints where dislocation can occur are: If you have a painful toe injury, you should seek emergency care immediately. 2005-2022 Healthline Media a Red Ventures Company. Treatment for Medial calcaneal nerve entrapment Rest. It can usually be straightened out (reduced) in a doctors office without surgery. A bone bruise does not show up on an X-ray. Any of your toes can become dislocated. Theyll also want to be sure there isnt an accompanying chip or fracture to the bone. intense pain that can be either dull or sharp, pain that radiates elsewhere in the foot or ankle, pain when putting weight on the injured area, swelling around the toe and sometimes into the foot, discoloration, such as black or blue bruising, around the toe, a change in the shape of the toe, if a bone is out of place, significant pain when walking or putting weight on the toe, a visible bone poking into the skin, which can occur after trauma, such as closing the toe in a heavy door, bleeding along the edge of, or underneath, the toenail, fluid or pus collecting under the skin around the nail, pain or itching around the toenail, even many months after the injury. Mid & Forefoot Trauma High Ankle Sprain & Syndesmosis Injuries are traumatic injuries that affect the distal tibiofibular ligaments and most commonly occur due to sudden external rotation of the ankle. Jones fractures may be caused by a specific traumatic event or a chronic overuse situation. Try gently taping a broken toe to a nearby toe. MRI imaging may also be done. Lesser toe deformities [Abstract]. activation and reduce unnecessary strain on already stressed soft tissue. At the doctors office or emergency clinic, merckmanuals.com/home/injuries-and-poisoning/dislocations/overview-of-dislocations, winchesterhospital.org/health-library/article?id=912642, fairview.org/sitecore/content/Fairview/Home/Patient-Education/Articles/English/t/o/e/_/d/Toe_Dislocation_116625en, Everything You Should Know About a Broken Toe, Reducing a Dislocated Shoulder, Yours or Someone Elses, Identifying and Treating a Dislocated Finger, How to Identify and Treat Shoulder Subluxation, Klinio Review for 2023: A Comprehensive Overveview, Lazarus Naturals CBD Products: A Review for 2023, severe pain (you may hear a snap or tearing sound), an angiogram to see if there are damaged blood vessels; this is usually not necessary except in unusual cases, nerve conduction studies to assess nerve damage; this might be done after the toe dislocation is reduced but rarely needed, distal interphalangeal (DIP), or outer joint, proximal interphalangeal (PIP), or middle joint (not present in big toe), metatarsophalangeal (MTP) joint, where your toe joins to your foot. Cold therapy. Nabi W, et al. Strains, sprains, bone contusions, and broken toes can all feel very similar. If the impact from stubbing a toe causes broken skin or nails, bacteria can enter the skin to cause an infection. It occurs when a childs elbow is pulled and partially dislocates. Stubbing a toe can even cause breaks, sprains, broken nails, and infections. Cancer treatment shows promise against multiple sclerosis in mouse study, Alzheimer's: Blood test may detect 'toxic' protein years before symptoms emerge, Low levels of vitamin D in the brain linked to increased dementia risk, How to treat a broken toe, and how to know if it is broken. Foot drop is a gait abnormality in which the dropping of the forefoot happens due to weakness, irritation or damage to the deep fibular nerve (deep peroneal), including the sciatic nerve, or paralysis of the muscles in the anterior portion of the lower leg.It is usually a symptom of a greater problem, not a disease in itself. There is little fat to cushion the toes, which can intensify the pain and increase the risk of injuries such as bone bruises and fractures. A Controlled Ankle Motion (CAM) boot also known as a Moon Boot is an orthopedic device prescribed for the treatment and stabilization of severe sprains, fractures, tendon or ligament tears in the ankle or foot. Do you know the signs of a dislocated finger? A strain is an injury to a muscle or tendon. Pain is usually located towards the middle, or front of the foot. When they occur traumatically, it's usually the result of an inversion-type sprain, which is one where the foot is turned inward towards the other foot. This fracture may not be easily identified and sometimes can be mistaken for a non-healing ankle sprain. Plus, learn home remedies and what, Hammer toe is a condition that tends to form gradually from wearing shoes that are too tight. You can learn more about how we ensure our content is accurate and current by reading our. It can also happen from an injury to your foot or toe. Mortons neuroma or Mortons syndrome is a compressed nerve in your forefoot, causing pain between the third and fourth toes. Unlike the non-operative treatment of a lateral ligament rupture, non-operative treatment of avulsion fractures does not yield satisfactory results. When the pain does not go away, it may mean that there is a more serious injury. Reduce frequency to 3 to 4 times per day as your symptoms improve. Treatment may involve splinting or buddy taping the affected toe. This helps prevent swelling. Symptoms are made worse with weight-bearing activities such as walking, running or dancing. Plantar Fascia Strain (Foot Arch Strain) A Plantar fascia strain is a strain of the plantar fascia that forms the arch of the foot. A sprain is an injury to the ligaments that connect the bones of the toe. However, dont take these medications until approved by your physician in case a general anesthetic may be used to reduce the dislocation. A dislocated toe is a fairly common injury, especially in contact sports like football. Wilkerson G B, Horn-Kingery H M. Treatment of the inversion ankle sprain: comparison of different modes of compression and cryotherapy. Pain in the forefoot that develops gradually over time. We explain the symptoms and how this injury is treated. In some cases, however, the impact could break the toe or the toenail, causing intense pain that may get worse over hours or days. Here we explain the symptoms, (2017). They include: Stubbed toes can hurt a lot, even when the injury is not serious. You may be told to remove it for sleeping and bathing. Your doctor may give you a pain reliever or muscle relaxant to make the examination less painful. It can take 69 months for a subungual hematoma to disappear. Shirzad K, et al. Take an over-the-counter pain reliever. Irreducible dislocation of the fourth metatarsophalangeal jointA case report. The big toe has only two large phalanxes. The symptoms of a stubbed toe are similar at first, regardless of whether the injury is serious or minor. Treatment is nonoperative for syndesmotic sprains without diastasis or ankle instability. This is the same type of injury that can cause an ankle fracture. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. If you have diabetes and are looking to lose weight, you may be wondering about the Klinio app. Stabilization of the midfoot is based on the ligamentous and bony integrity of the second TMT joint. Apply an ice pack or some ice wrapped in a towel to reduce pain and swelling. A Lisfranc injury, also known as Lisfranc fracture, is an injury of the foot in which one or more of the metatarsal bones are displaced from the tarsus.. It can be very painful and make it difficult to walk. Reusable Gel Dancer's Pads relieve forefoot and ball of foot pain by shifting weight away from the great toe joint and sesamoid bones. This isnt effective while seated in a chair or couch. The exact location of the pain depends on which of the many foot ligaments has sprained (torn). Treatment is generally observation as most are completely asymptomatic. The treatment for a dislocation is to reposition the bones into the proper alignment. Apply a numbing cream or spray to an injured toenail. Massaging or shaking the area sometimes helps. Rest as much as possible and avoid putting pressure on your foot. J Orthop Sports Phys Ther. Each of your toes, except the big toe, has three bones known as phalanxes or phalanges. Latex free. Walk slowly across the floor. Hypertension: Can 15 minutes of yoga a day help control blood pressure? Apply directly to the skin. Broken toes and sprained toes share many causes and symptoms. A sprain is an injury to the ligaments that connect the bones of the toe. Heres why this happens, tips for identification, treatment, and more. Children and athletes are at greater risk because of their stressful and riskier activity. Peroneus Brevis (also known as Fibularis Brevis) is a short muscle that lies in the lateral part of the lower leg deep to the Peroneus Longus.. Hematomas, regardless of size, often cause the toenail to fall off. Neglected irreducible dislocation of the interphalangeal joint of the great toe: A case report [Abstract]. Hindfoot: There are two bones in the hindfootthe talus, which is where the foot attaches to the ankle and the rest of the leg, and the calcaneus, which forms the heel. Nonsteroidal anti-inflammatory drugs help reduce pain and, Try rest, ice, compression, and elevation (. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Mild strains and sprains may just stretch a ligament, muscle, or tendon. Severe hematomas can cause large blood spots and intense, painful pressure. Help your child do any recommended exercises. Last medically reviewed on November 16, 2018. To help plan treatment for turf toe, doctors grade the injuries from 1 to 3 mild to severe. People over 65 are more likely to dislocate a joint. DOI: Hatori M, et al. Learn more about the differences between sprains and strains here. Campagne D. (n.d.). Skin infections along the nail are called paronychia. If their doctor put a removable splint on the toe, make sure your child wears it as prescribed. There may be a specific tender spot on the bone where the fracture is located. Treatment of peroneal nerve contusion. Epidemiology of joint dislocations and ligamentous/tendinous injuries among 2,700 patients: Five-year trend of a tertiary center in Iran. This can be difficult, but explain that this is the way to get better faster. A midtarsal joint sprain is an injury or tear to any of the ligaments holding the midtarsal bones together. A dislocation is a complete separation of the bones in a joint. (2013). A stubbed toe is the name for any injury that happens when a person suddenly hits or jams their toe. In rare cases, the dislocated bones cannot be repositioned because of internal injuries. There may be swelling on the outside and/or top of the foot. Midtarsal Joint Sprain. This should always be done by a doctor or medical professional. Well share, Stubbed toes happen to everyone. Lie down and prop your foot up so its higher than your heart. If symptoms do not improve after a few minutes, it may mean that the toe is broken. You may also be given crutches to keep the weight off the injured toe. What is turf toe and how do you treat it? Youll be given general anesthesia by injection or a face mask. People with diabetes or a weakened immune system are more vulnerable to toe and foot infections. Case report: Irreducible dislocation of the great toe interphalangeal joint secondary to an incarcerated sesamoid. A stubbed toe may seem to be a minor injury. (2016). A normal foot will leave a print of the heel, connected to the forefoot by a strip approximately half the width of the foot on the outside of the sole. Dont immediately return to your usual level of activities. Pain relievers including aspirin, ibuprofen (Motrin, Advil), and acetaminophen (Tylenol) can help manage the pain. This is because there are many nerves in the toe, including two nerves on either side. Irreducible dislocation of the proximal interphalangeal joint of the second toe in a six-year-old child: A case report [Abstract]. Learn about seven common causes, including their symptoms and, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. When standing, as your foot rolls inwards, the arch of your foot flattens. We avoid using tertiary references. (269.3 grams), womens: 8.2 oz. A midtarsal joint sprain is an injury to any of the ligaments holding the midtarsal joints together. But injury to the second toe is more common, according orthopedic surgeon A. Holly Johnson, MD, a board member of the American Orthopaedic Foot & Ankle Foundation. Closed reduction is when the bones are repositioned by external manipulation, without surgery. Realignment of the bones in a joint is known as reduction. If you suspect a Lisfranc injury or even a midtarsal joint sprain, then seek medical advice immediately. Apply ice or cold therapy for 10 minutes every hour initially. Wearing proper footwear and avoiding unnecessary risk in sports and other activities can help prevent a toe dislocation. Turf toe is a sprain of the main joint of the big toe. Symptoms include: Pain on the outside of the midfoot. Foot drop is characterized by inability or impaired ability to The calf muscles consist of the larger gastrocnemius muscle and the lower soleus muscle. Unlike plaster casts, CAM Boots are adjustable. Comparison of the effects of forefoot joint-preserving arthroplasty and resection-replacement arthroplasty on walking plantar pressure distribution and patient-based outcomes in patients with rheumatoid arthritis [Abstract]. Often, the ligaments that hold your bones together are torn. (2017). Ebina K, et al. The injury is named after Jacques Lisfranc de St. Martin, a French surgeon and gynecologist who noticed this fracture pattern amongst cavalry men, in 1815, after the War of the Sixth Coalition. Pain will be felt on the outside middle of the foot. treatment required will vary based on the severity (grade) of the injury. The treatment is rest and avoidance of weight bearing. The first step to finding, Whether you can get immediate medical attention or are hours away from help, there are basic things you can do for a dislocated shoulder. Have your child lie down and prop up their foot on a pillow when icing. Learn about pros, cons, and top products here. The symptoms of a bone bruise, strain, and sprain are similar to those of a broken toe. If your doctor suspects a dislocation, theyll probably take an X-ray to confirm it. Physical therapy and special exercises may be prescribed. It might result from one single traumatic incident, resulting in sudden pain, or may gradually occur over a period of time through overuse. Overview of dislocations. However, more severe injuries can tear the tissue. A certain amount of this is natural and necessary. Make sure you fully understand the instructions so you can supervise them. Its also common in activities that involve jumping. This article looks at the symptoms of a stubbed toe, how to tell if a toe is broken or sprained, some treatments, and a range of home remedies. The . Mild strains and sprains may just stretch a ligament, muscle, or tendon. This damage can occur when pushing down on, Big toe pain has several possible causes, with some being more serious than others. Keep these things in mind as you recover from a dislocation: A dislocated toe is a serious injury, and you can usually recognize it by the pain, swelling, and crooked appearance of the toe. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. It requires specialized surgery to deal with the additional internal injury. Soak an injured toenail in warm water or Epsom salts. Healthline Media does not provide medical advice, diagnosis, or treatment. However, it can be intensely painful. Here is a look at some of the top recommended products for non-surgical treatment of hallux limitus: (2018). Treatment for a broken ankle depends on the exact site and severity of the bone fracture. is the only over-the-counter orthotic insert that allows completely adjustable treatment of hallux limitus by placing removable wedges under the great toe joint. It's the ideal ice pack for injuries. Dislocation occurs at one of the joints where the phalanx bones come together. The Lisfranc joint complex includes the bones and ligaments that connect the midfoot and forefoot. In most cases, people can treat the injury at home and medication can help with the pain. We review the pros, cons, pricing, and more. Learn more about a, A broken pinky toe can cause swelling and pain. Talar neck fractures often have difficulty healing because of poor blood supply. Symptoms include pain on the outside middle of the foot, but the exact location will depend on which particular ligament is injured. Its not as severe as a break, which involves a bone injury, but it can still be quite painful, A broken toe can be very painful, but its usually easy to treat. There are two types of reduction: closed and open. Use the knee ice pack to be ready for sports, therapy treatment for Meniscus tears or ACL or MCL surgery. Or they may inject a local anesthetic near the injured area. They can be intensely painful, but they will usually heal within a couple of months. Our website services, content, and products are for informational purposes only. Its possible to have a dislocation and a chip or fracture of one of the bones of the toe at the same time. The symptoms and severity of a midtarsal joint sprain will depend on which ligaments have been sprained. Stubbing the toe can result in several different injuries: A broken toe or a toe fracture is a break in one of the 14 toe bones. Do not apply ice directly to the skin as it may cause ice burns. Treatment involves reducing initial pain and inflammation along with a program of stretching and strengthening exercises. Keep this on for 10 to 20 minutes every hour for the first few hours, until you can get help. (2015). It makes the ideal ice wrap for knee or elbow. Peroneal tendon tear symptoms. Midfoot: Five smaller foot bones called the navicular, cuboid, and three cuneiform bones make up the A stubbed toe can be extremely painful. Foot sprains are an acute condition but may require weeks or months of treatment to recover function. Symptoms of a peroneus brevis tendon tear include: Pain on the outside of your foot, specifically over the prominent bony part on the outside of the forefoot. Our articles and other resources provide in-depth information about symptoms, causes, and treatment options for musculoskeletal problems and all of our resources are developed and reviewed by the experts at the American Academy of You may have swelling on the top of your foot. You may also hear a tearing or snapping noise. If the injury is serious enough to bleed, it may be painful to walk for several weeks. The reusable cold pack gives relief for injuries, surgery, recovery or treatment from running or jogging. Youll be given a splint and possibly specialized footwear to keep the toe in alignment while the injury heals. A short period of limited weight-bearing may be necessary to allow the ligament to heal and therefore the swelling and pain to subside. We avoid using tertiary references. Injuries to the toenails can be very painful, especially if the toenail breaks deep in the nail plate. footEducation.com was created by orthopaedic surgeons to provide patients and medical providers with current and accurate information on foot and ankle conditions and their treatments. Lisfranc ligament, the interosseous ligament that runs obliquely from the second metatarsal base to the medial cuneiform, is the largest midfoot ligament and along with the second plantar ligament (intermetatarsus ligament between the second and the third Learn more about toe fractures and other conditions that can cause these symptoms, plus treatment, Click here to learn how to recognize the symptoms of a broken toe, find out what treatments can help, and get some tips for preventing injury to the, Turf toe is a common sports injury that occurs when the bones and tissue around the big toe become damaged. The goal of all treatment is to stabilize the foot, support the arches, stabilize the big toe, reduce movement of the big toe, and provide shock absorption. Specific treatment options include rest, immobilization, pain medication, and possible surgery. MNT is the registered trade mark of Healthline Media. It occurred more frequently in American football players after artificial turf became more common on playing fields. You can learn more about how we ensure our content is accurate and current by reading our. Exercises. Prevent the toe from moving. A CT scan may be done to see if small fractures are present. Price: $$ Weight: mens: 9.5 oz. Dont use these pain relievers with young children, and follow appropriate dosing for older children. Nursemaid elbow is a common elbow injury, especially among children and toddlers. Razak HRBA, et al. A sprained toe refers to a toe with a torn ligament. The Peroneus Brevis along with the Peroneus Longus are commonly injured during a lateral ankle sprain In a pure dislocation, the bones are still intact, but theyve moved out of their normal position at the joint. Continuing to train when the foot is painful will only make the injury worse and delay the healing. Swelling on the outside or top of the joint. A strain is an injury to a muscle or tendon. In the event of symptoms, treatment depends on location of Os and chronicity of symptoms. Symptoms of an ankle avulsion fracture are very similar to an ankle sprain and it is very difficult to The treatment for a dislocation is to reposition the bones into the proper alignment. Paronychia: What you should know. Lets look at the most likely symptoms youll experience if youve dislocated a toe. It is one of the three ankle everters known as the peroneus muscles (Pernoeus Longus, Peroneus Brevis and Peroneus Tertius).. The big toe may be wrapped with an elastic bandage to keep it in alignment, and may have a cast. Nabian MH, et al. Midfoot sprain treatment and recovery time. Hey HW, et al. Medically reviewed by Dr Chaminda Goonetilleke, 4th Jan. 2022. Extensor tendonitis treatment. Sometimes the toenail falls off, either right after stubbing the toe or weeks later. Youll feel sharp pain and experience swelling, and sometimes bruising. Pronation occurs when your foot naturally rolls inwards. This is because weight is transferred from the heel to the forefoot. Make sure your child rests. (2006). An ACL sprain (torn ACL) is a tear of the anterior cruciate ligament in the knee joint. A bone bruise is a deep bruise that injures blood vessels in or around the bone. For severe cases, surgical intervention may be necessary. (2017). Rest. Learn more about the symptoms of a broken or sprained toe. Dont wait to see what happens. Waiting can result in complications and permanent damage, especially as you continue to walk on or stay on your feet. A Lisfranc fracture is a type of bone fracture that occurs in the middle of the foot, affecting ligaments and metatarsals. How Viagra became a new 'tool' for young men, The amazing story of hepatitis C, from discovery to cure, Ankylosing Spondylitis Pain: Fact or Fiction. Midtarsal Joint Sprain. This is called an irreducible dislocation. Open reduction is a surgery done in the operating room. Treatment depends on the cause of your injury. Wear shoes with padding or a stiff sole for protection and support. The pathology and management of lesser toe deformities. The pain of a stubbed toe usually subsides after a few minutes. Last medically reviewed on August 5, 2019, A sprained toe is a common injury that is often tender and painful. Your foot will be tender to touch. The contributors to this site are all board certified orthopaedic surgeons who specialize in treating patients with foot and ankle problems. But children recover faster than adults from dislocations, as with most injuries. Although many toe injuries heal on their own, prompt medical care can speed healing and help with the pain. DOI: Malhotra K, et al. The foot has 26 bones and is divided into three parts: the hindfoot, the midfoot, and the forefoot. If the injury is more serious, a number of strategies can help with the pain: If the injury is severe, a doctor might recommend surgery or physical therapy. This should always be done by a doctor or medical professional. Some people are able to return to regular activities within a day or two. Shoulder subluxation refers to a partial dislocation of your shoulder. It can be difficult to self-diagnose a stubbed toe. If supination is a problem, the prints of the heel and forefoot will be connected by only a thin strip on the outside, or may not even be connected, as shown opposite. Well explain the common symptoms and which ones mean a visit to your doctor. They can take a long time to heal and may also require surgery. But a sprain usually heals faster than a dislocation or a fracture. Wondering how Lazarus Naturals CBD products stack up? ; Pain will most likely come on suddenly after a twisted ankle, or sudden forced movement of the ankle. Treatment. Correcting over-supination Rest from all aggravating activities. At OrthoInfo, our goal is to help you get the information you need to make informed decisions about your health care. Your toe may look crooked or out of alignment. The foot must be higher than the heart so the fluids that cause swelling can drain. Supplements for heart health: Which ones are beneficial and which ones are not? All rights reserved. If the skin is broken, it is important to keep the toe clean and covered and to see a doctor for symptoms of an infection. Dont walk on a toe that may be dislocated. Tibialis posterior tendonitis running exercises After stubbing the toe, massaging or shaking the foot can distract from the pain and increase blood flow. (2011). 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